TY  - JOUR
TI  - HMG-17, a chromosomal non-histone protein, shows developmental regulation during organogenesis.
AU  - Lehtonen, S
AU  - Olkkonen, V M
AU  - Stapleton, M
AU  - Zerial, M
AU  - Lehtonen, E
T2  - The International Journal of Developmental Biology
AB  - We used the differential hybridization technique for isolating developmentally regulated genes from the mouse metanephric kidney. In this screening, we identified the cDNA encoding high-mobility-group protein 17 (HMG-17), a chromosomal non-histone protein which modulates the conformation of transcriptionally active chromatin. Using Northern blot analysis, the HMG-17 mRNA was strongly expressed during embryogenesis and downregulated in various adult murine organs. At the histological level, the transcript localized to differentiating tissue regions and was apparently downregulated in mature structures indicating that HMG-17 expression is linked to cell differentiation. HMG-17 can thus be regarded as a general marker for tissues or cells undergoing differentiation during organogenesis.
PY  - 1998
VL  - 42
IS  - 6
SP  - 775
EP  - 782
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/9727833
Y2  - 2024/11/05/21:52:01
ER  -