TY  - JOUR
TI  - Cell-cycle-dependent nuclear translocation of HSP70 in amphibian embryonic cells.
AU  - Moreau, N
AU  - Prudhomme, C
AU  - Angelier, N
T2  - The International Journal of Developmental Biology
AB  - Using immunocytochemical methods, we analyzed the localization of the HSP70 protein constitutively expressed during embryogenesis in the amphibian Pleurodeles waltl. Our results provide evidence for nuclear transfer of the protein during gastrulation, and particularly for predominant nuclear labeling in gastrula internalized cells. Using two inhibitors of DNA replication -hydroxyurea (HUA) and aphidicolin- or/and an inhibitor of transcription -actinomycin D- applied to embryos, we demonstrated that nuclear transfer of HSP70 is related to the transcriptional activity of the cells during the early S phase of the cell cycle.
PY  - 1998
VL  - 42
IS  - 4
SP  - 633
EP  - 636
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/9694637
Y2  - 2024/11/05/17:21:24
ER  -