TY  - JOUR
TI  - Identification of elf1, a beta-spectrin, in early mouse liver development.
AU  - Mishra, L
AU  - Cai, T
AU  - Levine, A
AU  - Weng, D
AU  - Mezey, E
AU  - Mishra, B
AU  - Gearhart, J
T2  - The International Journal of Developmental Biology
AB  - Beta-spectrins play essential roles in cell-cell interactions and in the maintenance of cell polarity. Our aim was to identify beta-spectrin genes important for the establishment of hepatocyte polarity and differentiation. Using subtractive screening of cDNA libraries from early embryonic mouse livers (post-coital days 10, 11, and 12), we have isolated elf1 (embryonic liver fodrin 1), a differentially expressed beta-spectrin or fodrin (betaSpIIsigmaI). Elf1 encodes a 220-amino acid protein with an NH2 terminal actin-binding domain. In situ hybridization studies demonstrate elf1 expression initially in day 10 embryonic heart tissue, then in day 11-11.5 hepatic tissue. These studies suggest that elf1 may play a role in the emergence of hepatocyte polarity during liver development.
PY  - 1998
VL  - 42
IS  - 2
SP  - 221
EP  - 224
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/9551868
Y2  - 2024/11/05/15:23:28
ER  -