TY  - JOUR
TI  - Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily.
AU  - Oulad-Abdelghani, M
AU  - Chazaud, C
AU  - Bouillet, P
AU  - Mattei, M G
AU  - Dolle, P
AU  - Chambon, P
T2  - The International Journal of Developmental Biology
AB  - We report the structure, chromosomal localization and expression features of Stra3, a novel mouse gene whose expression is upregulated by retinoic acid in P19 embryonal carcinoma cells. The Stra3 cDNA sequence, which encodes a novel member of the TGF-beta superfamily, corresponds to, but extends more 3' than the recently published lefty sequence (Meno et al., 1996, Nature 381:151-155). The Stra3/lefty protein, which exhibits characteristics of secreted proteins, is synthesized as a precursor of 42 kDa and secreted after cleavage, suggesting that it may function as an intercellular signaling molecule. There are four exons in the Stra3/lefty gene and its 5' flanking region contains, among other putative regulatory elements, an unusual retinoid response element consisting of two half sites arranged as a palindrome, with an 8 base pairs spacer. We also show that Stra3/lefty is ectopically induced in the endodermal and ectodermal layers following in vivo administration of retinoic acid to gastrulating mouse embryos.
PY  - 1998
VL  - 42
IS  - 1
SP  - 23
EP  - 32
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/9496783
Y2  - 2024/11/05/17:18:28
ER  -