TY  - JOUR
TI  - Cell reproduction: induction of M-phase events by cyclin-dependent cdc2 kinase.
AU  - Kishimoto, T
T2  - The International Journal of Developmental Biology
AB  - Although a major concern in the development of multicellular organisms is cell differentiation, the construction of a multicellular system essentially depends on cell multiplication, which consists of genomic duplication and segregation. Recent progress has revealed that cyclin-dependent kinases (CDKs) are key components of a cell cycle engine that governs cell proliferation. This article focuses on how CDKs induce M-phase events characterized by nuclear membrane breakdown, chromosome condensation and mitotic spindle formation to assure genomic segregation.
PY  - 1994
VL  - 38
IS  - 2
SP  - 185
EP  - 191
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/7981028
Y2  - 2024/12/04/20:25:58
ER  -