TY  - JOUR
TI  - Developing blood vessels and associated extracellular matrix as substrates for neural crest migration in Japanese quail, Coturnix coturnix japonica.
AU  - Spence, S G
AU  - Poole, T J
T2  - The International Journal of Developmental Biology
AB  - Japanese quail embryos were used to examine paths of neural crest cell (NC) migration in relationship to the embryonic vasculature. Immunolabeling for NC, angioblasts and the extracellular matrix (ECM) glycoproteins fibronectin (FN), laminin (LN) and tenascin (TN) revealed several instances where spatiotemporal patterns of NC migration coincide with the embryonic vascular pattern and its associated ECM. An in vitro model for angiogenesis was modified to include NC, and associations with "capillary-like" endothelial cell structures were demonstrated. A working hypothesis is that the embryonic vasculature may, in specific instances, be used as a substratum for directed NC migration and that these interactions are mediated primarily through the adhesive interactions of FN. Some members of the TN family of glycoproteins, through their relatively non-adhesive properties, may act to help guide neural crest cells to the FN-rich blood vessel surface.
PY  - 1994
VL  - 38
IS  - 1
SP  - 85
EP  - 98
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/7521199
Y2  - 2024/11/24/04:35:07
ER  -