TY  - JOUR
TI  - Sialylated glycoproteins and sialyltransferases involved in mesoderm-derived organ formation during embryogenesis
AU  - Fliniaux, Ingrid
AU  - Douchez, Pélagie
AU  - Takeda-Uchimura, Yoshiko
AU  - Matthieu, Marin
AU  - Martoriati, Alain
AU  - Yamakawa, Nao
AU  - Molinaro, Caroline
AU  - Bodart, Jean François
AU  - Harduin-Lepers, Anne
AU  - Cailliau, Katia
T2  - The International Journal of Developmental Biology
AB  - Most major organs, like muscles, bones, vessels and kidneys, develop from the mesoderm, one of three germ cell layers in triploblastic organisms. Sialic acids significantly affect embryonic development by regulating cell division, migration and death through signaling pathways and cell adhesion, which support morphogenesis. Loss of early biosynthetic enzymes reduces embryonic viability and leads to complex phenotypes, while the loss of terminal enzymes primarily results in tissue-specific defects in mesoderm-derived organs. Key sialylated glycoproteins involved in the developmental processes of mesoderm and mesoderm-derived organs have been identified across various species as major effectors. These enzymes and glycoproteins are of significant interest and are discussed in the present review.
PY  - 2025
DO  - 10.1387/ijdb.250129km
VL  - 69
IS  - 4
SP  - 161
EP  - 172
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/250129km
Y2  - 2026/04/06/21:11:14
ER  -