TY - JOUR TI - The Hydra FGF family – dispersed across the genome and expressed locally AU - Ohler, Kerstin AU - Reichart, Lisa AU - Kneifert, Lars AU - Önel, Susanne AU - Hassel, Monika T2 - The International Journal of Developmental Biology AB - Although the nonbilaterian Hydra has a simple body architecture, its signaling systems are as complex as those of Bilateria. We here add data to the fibroblast growth factor signaling system which has previously been identified in Hydra as essential for bud detachment. The localized expression patterns of its, now fifteen, FGFs indicate additional, yet unidentified, functions in sometimes very small subsets of cells at the body termini and/or during budding or in testes. Presence of a typical signal sequence (prediction >93%) in only 30% of the Hydra FGFs suggests mechanisms of action (and/or secretion) other than the canonical ones. A knockdown approach using siRNA revealed a potential role for Hv-FGF-c in tentacle morphogenesis. Our results document a high complexity of FGF signaling sites in Hydra and open the field for a detailed analysis of their functions. PY - 2025 DO - 10.1387/ijdb.250118mh VL - In Press IS - In Press SP - 118 EP - 118 J2 - Int. J. Dev. Biol. LA - en SN - 0214-6282 SN - 1696-3547 UR - https://ijdb.ehu.eus/article/250118mh Y2 - 2025/12/25/17:29:20 ER -