TY  - JOUR
TI  - The Genetic Odyssey of Axolotl Regeneration: Insights and Innovations
AU  - Faisal, Muhammad
AU  - Mehreen, Afshan
AU  - Hays, Deli
AU  - Yaseen, Faiza
AU  - Liang, Yujun
T2  - The International Journal of Developmental Biology
AB  - The axolotl, a legendary creature with the potential to regenerate complex body parts, is positioned as a powerful model organism due to its extraordinary regenerative capabilities. Axolotl can undergo successful regeneration of multiple structures, providing us with the opportunity to understand the factors that exhibit altered activity between regenerative and non-regenerative animals. This comprehensive review will explore the mysteries of axolotl regeneration, from the initial cellular triggers to the intricate signaling cascades that guide this complex process. We will delve deeply into the multifaceted interplay of genes and factors, highlighting the key role of signaling pathways and the influence of epigenetic modifications (such as DNA methylation, histone modification, and miRNA regulation) during regeneration. Furthermore, we will discuss how axolotls defy the odds by showing remarkable resistance to cancer, offering insights into potential therapeutic strategies. However, that is not the end; we will also highlight how age might affect the regenerative power of this creature. We hope this review will help navigate the awe-inspiring realm of axolotl regeneration, advance our understanding of regenerative biology, and chart pathways for future investigations aimed at uncovering new therapeutic approaches.      
PY  - 2024
DO  - 10.1387/ijdb.240111yl
VL  - 68
IS  - 3
SP  - 103
EP  - 116
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/240111yl
Y2  - 2024/12/22/03:31:48
ER  -