TY  - JOUR
TI  - DUX4, the rockstar of embryonic genome activation?
AU  - Nykänen, Sonja
AU  - Vuoristo, Sanna
T2  - The International Journal of Developmental Biology
AB  - During the initial days of development, the embryo gradually shifts from reliance on maternally provided RNAs and proteins to regulation of its own development. This transition is marked by embryonic genome activation (EGA). While the factors driving human EGA remain poorly characterized, accumulating evidence suggests that double homeobox 4 (DUX4) is an important regulator of this process. Despite advances in single-cell methods which have allowed studies in early human embryos, fundamental questions regarding the function and regulation of DUX4 persist. Here, we review current knowledge of DUX4 with a focus on EGA in humans.
PY  - 2024
DO  - 10.1387/ijdb.230247sn
VL  - In Press
IS  - In Press
SP  - 247
EP  - 247
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/230247sn
Y2  - 2024/06/30/14:38:18
ER  -