TY  - JOUR
TI  - The GLI code controls HNF1A levels during foregut differentiation
AU  - Unger, Lucas
AU  - Mathisen, AndreasF.
AU  - Chera, Simona
AU  - Legøy, Thomas Aga
AU  - Ghila, Luiza
T2  - The International Journal of Developmental Biology
AB  - Differentiation of human induced pluripotent stem cells towards pancreatic islet endocrine cells is a complex process, involving the stepwise modulation of key developmental pathways, such as the Hedgehog signaling inhibition during early differentiation stages. In tandem with this active inhibition, key transcription factors for the islet endocrine cell fate, such as HNF1A, show specific changes in their expression patterns. Here we designed a pilot study aimed at investigating the potential interconnection between HH-signaling inhibition and the increase in the HNF1A expression during early regeneration, by inducing changes in the GLI code. This unveiled a link between the two, where GLI3-R mediated Hedgehog target genes inhibition is apparently required for HNF1A efficient expression.
PY  - 2024
DO  - 10.1387/ijdb.230220lg
VL  - In Press
IS  - In Press
SP  - 220
EP  - 220
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/230220lg
Y2  - 2024/11/21/14:55:06
ER  -