TY  - JOUR
TI  - Enhancer-promoter communication in <em>Drosophila</em> developmental gene transcription
AU  - Hunt, George
AU  - Mannervik, Mattias
T2  - The International Journal of Developmental Biology
AB  - Enhancers play an essential role in gene regulation by receiving cues from transcription factors and relaying these signals to modulate transcription from target promoters. Enhancer-promoter communications occur across large linear distances of the genome and with high specificity. The molecular mechanisms that underlie enhancer-mediated control of transcription remain unresolved. In this review, we focus on research in Drosophila uncovering the molecular mechanisms governing enhancer-promoter communication and discuss the current understanding of developmental gene regulation. The functions of protein acetylation, pausing of RNA polymerase II, transcriptional bursting, and the formation of nuclear hubs in the induction of tissue-specific programs of transcription during zygotic genome activation are considered.			
PY  - 2024
DO  - 10.1387/ijdb.230218gh
VL  - In Press
IS  - In Press
SP  - 218
EP  - 218
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/230218gh
Y2  - 2024/07/03/05:29:58
ER  -