TY  - JOUR
TI  - Strontium-doped hydroxyapatite and its role in osteogenesis and angiogenesis
AU  - Ran, Ling
AU  - Liu, Lishuang
AU  - Gao, Jingjing
AU  - Pan, Yang
AU  - Ramalingam, Murugan
AU  - Du, Xiaoyu
AU  - Liu, Ying
AU  - Cheng, Lijia
AU  - Shi, Zheng
T2  - The International Journal of Developmental Biology
AB  - For the past 50 years, hydroxyapatite (HA) has been widely used in bone defect repair because it is the main inorganic component of the mineral phase of a human bone. Extensive preclinical and clinical studies have shown that strontium (Sr) can safely and effectively help prevent and treat bone diseases, including osteoporosis. These findings have resulted in the concept of integrating Sr and HA for bone disease management. The doped Sr can improve the physicochemical properties of HA and enhance its angiogenic and bone regeneration ability. Nevertheless, no study has reviewed the design strategy of Sr-doped HA (Sr-HA) to understand its biological roles. Therefore, in this article, we review recent developments in Sr-HA preparation and its effect on osteogenesis and angiogenesis in vitro and in vivo along with key suggestions for future research and development.
PY  - 2023
DO  - 10.1387/ijdb.230091lc
VL  - 67
IS  - 4
SP  - 137
EP  - 146
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/230091lc
Y2  - 2024/11/21/11:03:05
ER  -