TY  - JOUR
TI  - Intraflagellar transport 20 cilia-dependent and cilia-independent signaling pathways in cell development and tissue homeostasis
AU  - Jin, Fu-Chang
AU  - Zhou, Ming-hui
AU  - Chen, Jing-Jing
AU  - Lin, Yi
AU  - Zhang, Qi-Wei
AU  - Xu, Qiu-Xian
AU  - Zhang, Chang-Chun
AU  - Zhang, Zhen-Gang
T2  - The International Journal of Developmental Biology
AB  - Intraflagellar transport (IFT) is an essential condition for ciliogenesis. The primary cilia protrude like antennae and act as chemical or mechanical sensory organelles that coordinate specific receptor localization and signal transduction. IFT20 is the smallest molecule in IFT complex B, which is located in both the cilia and the Golgi complex. Recent studies have shown that IFT20 is a key molecule in multiple signaling pathways. Importantly, in the function of IFT20, signal transduction is not restricted to cilia, but is also involved in non-ciliary functions. Here we summarize current knowledge regarding IFT20-mediated signaling pathways and their relationship with cell development and tissue homeostasis, and analyse the cilia-dependent and cilia-independent mechanisms of IFT20 coordinated signaling pathways and potential crosstalk between the mechanisms. This review provides a comprehensive perspective on IFT20 coordinates signaling mechanisms in cell development and tissue homeostasis.
PY  - 2022
DO  - 10.1387/ijdb.220072fj
VL  - 66
IS  - 4-5-6
SP  - 333
EP  - 347
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/220072fj
Y2  - 2024/11/21/14:16:26
ER  -