TY  - JOUR
TI  - The development of MGE-derived cortical interneurons: An Lhx6 tale
AU  - Christodoulou, Ourania
AU  - Maragkos, Ioannis
AU  - Antonakou, Vassiliki
AU  - Denaxa, Myrto
T2  - The International Journal of Developmental Biology
AB  - The cerebral cortex contains two main neuronal cell populations: the excitatory pyramidal neurons and the inhibitory interneurons, which constitute 20-30% of all cortical neurons. Cortical interneurons are characterized by a remarkable morphological, molecular and functional diversity. A swathe of research activity over the last 20 years has sought to determine how cortical interneurons acquire their mature cellular and functional features, and has identified a number of transcription factors that function at different stages of interneuron development. Here, we review all current knowledge concerning the multiple functions of the “master regulator” - LIM-Homeodomain transcription factor Lhx6 - a gene expressed in the medial ganglionic eminence of the basal telencephalon that controls the development of somatostatin and parvalbumin expressing interneurons.
PY  - 2022
DO  - 10.1387/ijdb.210185md
VL  - 66
IS  - 1-2-3
SP  - 43
EP  - 49
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/210185md
Y2  - 2024/11/21/10:56:53
ER  -