TY  - JOUR
TI  - Biological notion of positional information/value in morphogenesis theory
AU  - Wang, Yue
AU  - Kropp, Jérémie
AU  - Morozova, Nadya
T2  - The International Journal of Developmental Biology
AB  - The notions of positional information and positional value describe the role of cell position in cell development and pattern formation. Despite their frequent usage in literature, their definitions are blurry, and are interpreted differently by different researchers. Through reflection on previous definitions and usage, and analysis of related experiments, we propose three clear and verifiable criteria for positional information/value. Then we reviewed literature on molecular mechanisms of cell development and pattern formation, to search for a possible molecular basis of positional information/value, including those used in theoretical models. We conclude that although morphogen gradients and cell-to-cell contacts are involved in the pattern formation process, complete molecular explanations of positional information/value are still far from reality.
PY  - 2020
DO  - 10.1387/ijdb.190342nm
VL  - 64
IS  - 10-11-12
SP  - 453
EP  - 463
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/190342nm
Y2  - 2024/11/05/11:20:38
ER  -