TY  - JOUR
TI  - Determination of organ size: a need to focus on growth rate, not size
AU  - Coelho, CarmenM.A.
T2  - The International Journal of Developmental Biology
AB  - The regulation of growth and the determination of organ-size in animals is an area of research that has received much attention during the past two and a half decades. Classic regeneration and cell-competition studies performed during the last century suggested that for size to be determined, organ-size is sensed and this sense of size feeds back into the growth control mechanism such that growth stops at the “correct” size. Recent work using Drosophila imaginal discs as a system has provided a particularly detailed cellular and molecular understanding of growth. Yet, a clear mechanistic basis for size-sensing has not emerged. I re-examine these studies from a different perspective and ask whether there is scope for alternate modes of size control in which size does not need to be sensed.
PY  - 2020
DO  - 10.1387/ijdb.190302cc
VL  - 64
IS  - 4-5-6
SP  - 299
EP  - 318
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/190302cc
Y2  - 2024/12/03/18:15:04
ER  -