TY  - JOUR
TI  - Actin assembly states in <I>Dictyostelium</I> <I>discoideum </I>at different stages of development and during cellular stress
AU  - Ishikawa-Ankerhold, HellenC.
AU  - Müller-Taubenberger, Annette
T2  - The International Journal of Developmental Biology
AB  - The actin cytoskeleton of non-muscle cells is essential for cellular structure and subcellular organization, and the dynamic regulation of actin assembly and disassembly is a prerequisite for motility. Pioneering work using Dictyostelium discoideum focused on the biochemical analysis of non-muscle actin, the identification of actin-regulating proteins and their specific functions during processes like cell migration, cytokinesis, phagocytosis, and morphogenesis. Although subsequent work in higher eukaryotes revealed that the processes regulating actin dynamics are often much more complex, results obtained by using Dictyostelium have been of fundamental importance because they have contributed significantly to our understanding of the actin cytoskeleton in higher eukaryotes. Dictyostelium is an accepted model system for studying fast moving cells, because the single cells of the organism share many similarities with cells of the immune system such as human neutrophils. Here we provide a brief overview on the milestones of research of the actin cytoskeleton taking advantage of Dictyostelium. Furthermore, we summarize how actin structures and cytoskeletal dynamics at different stages of development have been visualized, and give an overview on the current focus of research. In addition, we discuss results showing actin assembly states during phases of cellular stress and how stress-induced actin assembly states may contribute to our understanding of certain diseases.
PY  - 2019
DO  - 10.1387/ijdb.190256am
VL  - 63
IS  - 8-9-10
SP  - 417
EP  - 427
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/190256am
Y2  - 2024/11/05/13:18:56
ER  -