TY  - JOUR
TI  - The endocytic pathways of <I>Dictyostelium discoideum</I>
AU  - Vines, JamesH.
AU  - King, JasonS.
T2  - The International Journal of Developmental Biology
AB  - The formation and processing of vesicles from the cell surface serves many important cellular functions ranging from nutrient acquisition to regulating the turnover of membrane components and signalling. In this article, we summarise the endocytic pathways of the social amoeba Dictyostelium from the clathrin-dependent and independent internalisation of surface components to the engulfment of bacteria or fluid by phagocytosis and macropinocytosis respectively. Due to similarities with the professional phagocytes of the mammalian immune system Dictyostelium has been extensively used to investigate the complex remodelling and trafficking events that occur as phagosomes and macropinosomes transit through the cell. Here we discuss what is known about this maturation process in order to kill any potential pathogens and obtain nutrients for growth. Finally, we aim to put these studies in evolutionary context and highlight some of the many questions that remain in our understanding of these complex and important pathways.
PY  - 2019
DO  - 10.1387/ijdb.190236jk
VL  - 63
IS  - 8-9-10
SP  - 461
EP  - 471
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/190236jk
Y2  - 2024/05/06/13:53:43
ER  -