TY  - JOUR
TI  - Comparative analysis of <I>p4ha1</I> and <I>p4ha2</I> expression during <I>Xenopus laevis</I> development
AU  - Martini, Davide
AU  - Giannaccini, Martina
AU  - Guadagni, Viviana
AU  - Marracci, Silvia
AU  - Giudetti, Guido
AU  - Andreazzoli, Massimiliano
T2  - The International Journal of Developmental Biology
AB  - Collagen prolyl 4-hydroxylases (c-P4Hs) are evolutionary conserved enzymes whose activity is essential for the correct folding of stable triple helical molecules of collagen and collagen-like proteins. They play crucial roles in embryo development, connective tissue functional organization, tumor growth and metastasis. Despite the important function of these enzymes, little is known about their expression during vertebrate development. In this study, we determine and compare the previously undescribed spatio-temporal expression patterns of the p4ha1 and p4ha2 genes, which encode the main subunits containing the enzyme active site, during Xenopus development. The two genes are maternally inherited and share expression in dorsal mesoderm, branchial arches and their derivatives, as well as in the central nervous system, although with distinct spatio-temporal patterns. A major co-expression domain for p4ha1 and p4ha2 is represented by the developing notochord, where these genes are transcribed from early neurula stage to stage 42 tadpole, thus paralleling the profile of collagen II production and suggesting a coordination between collagen synthesis and its post-translational modifications.
PY  - 2019
DO  - 10.1387/ijdb.190067ma
VL  - 63
IS  - 6-7
SP  - 311
EP  - 316
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/190067ma
Y2  - 2024/11/21/14:09:51
ER  -