TY  - JOUR
TI  - <I>Hox</I> genes, clusters and collinearity
AU  - Krumlauf, Robb
T2  - The International Journal of Developmental Biology
AB  - This year marks the 40th anniversary of the discovery by Ed Lewis of the property of collinearity in the bithorax gene complex in Drosophila. This landmark work illustrated  the need to understand regulatory mechanisms  that coordinate expression of homeotic gene clusters. Through the efforts of many groups, investigation of the Hox gene family has generated many fundamental findings on the roles and regulation of this conserved gene family in development, disease and evolution. This has led to a number of important conceptual advances in gene regulation and evolutionary biology. This article presents some of the history and advances made through studies on Hox gene clusters.
PY  - 2018
DO  - 10.1387/ijdb.180330rr
VL  - 62
IS  - 11-12
SP  - 659
EP  - 663
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/180330rr
Y2  - 2024/12/21/19:25:04
ER  -