TY  - JOUR
TI  - Somatic cell nuclear transfer: failures, successes and the challenges ahead
AU  - Czernik, Marta
AU  - Anzalone, DeboraA.
AU  - Palazzese, Luca
AU  - Oikawa, Mami
AU  - Loi, Pasqualino
T2  - The International Journal of Developmental Biology
AB  - Somatic cell nuclear transfer (SCNT) has a broad spectrum of potential applications, including rescue of endangered species, production of transgenic animals, drug production, and regenerative medicine. Unfortunately, the efficiency of SCNT is still disappointingly low. Many factors affecting cloning procedures have been described in several previous reviews; here we review the most effective improvements in SCNT, with a special emphasis on the effect of mitochondrial defects on SCNT embryo/ foetus development, an issue never touched upon before.
PY  - 2019
DO  - 10.1387/ijdb.180324mc
VL  - 63
IS  - 3-4-5
SP  - 123
EP  - 130
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/180324mc
Y2  - 2024/11/21/13:51:38
ER  -