TY  - JOUR
TI  - Regulatory landscape of the Hox transcriptome
AU  - Casaca, Ana
AU  - Hauswirth, GabrielM.
AU  - Bildsoe, Heidi
AU  - Mallo, Moisés
AU  - McGlinn, Edwina
T2  - The International Journal of Developmental Biology
AB  - Precise regulation of Hox gene activity is essential to achieve proper control of animal embryonic development and to avoid generation of a variety of malignancies. This is a multilayered process, including complex polycistronic transcription, RNA processing, microRNA repression, long noncoding RNA regulation and sequence-specific translational control, acting together to achieve robust quantitative and qualitative Hox protein output. For many such mechanisms, the Hox cluster gene network has turned out to serve as a paradigmatic model for their study. In this review, we discuss current knowledge of how the different layers of post-transcriptional regulation and the production of a variety of noncoding RNA species control Hox output, and how this shapes formation of developmental systems that are reproducibly patterned by complex Hox networks.
PY  - 2018
DO  - 10.1387/ijdb.180270em
VL  - 62
IS  - 11-12
SP  - 693
EP  - 704
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/180270em
Y2  - 2024/04/27/18:05:58
ER  -