TY - JOUR TI - Regulatory landscape of the Hox transcriptome AU - Casaca, Ana AU - Hauswirth, GabrielM. AU - Bildsoe, Heidi AU - Mallo, Moisés AU - McGlinn, Edwina T2 - The International Journal of Developmental Biology AB - Precise regulation of Hox gene activity is essential to achieve proper control of animal embryonic development and to avoid generation of a variety of malignancies. This is a multilayered process, including complex polycistronic transcription, RNA processing, microRNA repression, long noncoding RNA regulation and sequence-specific translational control, acting together to achieve robust quantitative and qualitative Hox protein output. For many such mechanisms, the Hox cluster gene network has turned out to serve as a paradigmatic model for their study. In this review, we discuss current knowledge of how the different layers of post-transcriptional regulation and the production of a variety of noncoding RNA species control Hox output, and how this shapes formation of developmental systems that are reproducibly patterned by complex Hox networks. PY - 2018 DO - 10.1387/ijdb.180270em VL - 62 IS - 11-12 SP - 693 EP - 704 J2 - Int. J. Dev. Biol. LA - en SN - 0214-6282 SN - 1696-3547 UR - https://ijdb.ehu.eus/article/180270em Y2 - 2024/12/14/05:13:15 ER -