TY  - JOUR
TI  - The remote transcriptional control of <I>Hox</I> genes
AU  - Gentile, Claudia
AU  - Kmita, Marie
T2  - The International Journal of Developmental Biology
AB  - Since the discovery by Ed Lewis that the order of Hox genes on the chromosome reflects the partitioning of their patterning function along the anterior-posterior axis of the developing fruit fly embryo, extensive efforts have been dedicated to uncovering the regulatory events underlying the collinear expression of Hox genes. These studies have revealed various aspects of Hox regulation, including short-range and long-range transcriptional enhancers, insulator elements and non-coding RNAs. With the development of technologies allowing for high resolution probing of chromatin architecture, notably Chromosome Conformation Capture (3C)-based techniques, a clear relationship is emerging between long-range regulation of Hox genes and the three-dimensional organization of the genome. Here, we provide an overview of these studies and in particular we discuss the functional relevance of genome compartmentalization, CTCF- mediated insulation and the Polycomb Repressive Complexes in the remote control of Hox genes.
PY  - 2018
DO  - 10.1387/ijdb.180198mk
VL  - 62
IS  - 11-12
SP  - 685
EP  - 692
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/180198mk
Y2  - 2024/04/30/21:42:08
ER  -