TY  - JOUR
TI  - Hox and Tale transcription factors in heart development and disease
AU  - Lescroart, Fabienne
AU  - Zaffran, Stephane
T2  - The International Journal of Developmental Biology
AB  - Hox genes are highly conserved transcription factors with critical functions during development, in particular for patterning the antero-posterior axis of the embryo. Their action is very often associated with cofactors including the TALE family transcription factors. From Drosophila to vertebrates, Hox genes have been shown to have a major role in heart development. In this review, we focus on the increasing evidence implicating the anterior Hox genes and the Tale family members during heart development both in the cardiac mesoderm and in neural crest cells. Congenital heart defects are the leading cause of death in the first year of life and a better understanding of the role of Hox and Tale factors is highly relevant to human pathologies and will provide novel mechanistic insights into the underlying defects.
PY  - 2018
DO  - 10.1387/ijdb.180192sz
VL  - 62
IS  - 11-12
SP  - 837
EP  - 846
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/180192sz
Y2  - 2024/11/21/14:02:21
ER  -