TY  - JOUR
TI  - The chick limb: embryology, genetics and teratology
AU  - Davey, MeganG.
AU  - Towers, Matthew
AU  - Vargesson, Neil
AU  - Tickle, Cheryll
T2  - The International Journal of Developmental Biology
AB  - The chick embryo has a long history in investigations of vertebrate limb development because of the ease with which its limbs can be experimentally manipulated. Early studies elucidated the fundamental embryology of the limb and identified the key signalling regions that govern its development. The chick limb became a leading model for exploring the concept of positional information and understanding how patterns of differentiated cells and tissues develop in vertebrate embryos. When developmentally important molecules began to be identified, experiments in chick limbs were crucial for bridging embryology and molecular biology. The embryological mechanisms and molecular basis of limb development are largely conserved in mammals, including humans, and uncovering these molecular networks provides links to clinical genetics. We emphasise the important contributions of naturally occurring chick mutants to elucidating limb embryology and identifying novel developmentally important genes. In addition, we consider how the chick limb has been used to study mechanisms involved in teratogenesis with a focus on thalidomide. These studies on chick embryos have given insights into how limb defects can be caused by both genetic changes and chemical insults and therefore are of great medical significance.
PY  - 2018
DO  - 10.1387/ijdb.170315CT
VL  - 62
IS  - 1-2-3
SP  - 85
EP  - 95
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/170315CT
Y2  - 2024/12/21/19:30:05
ER  -