TY  - JOUR
TI  - The early development of germ cells in chicken
AU  - Kim, YoungMin
AU  - Han, JaeYong
T2  - The International Journal of Developmental Biology
AB  - Primordial germ cells (PGCs) are the founder cells for mature gametes, the vehicles by which individuals transmit genetic and epigenetic information to later generations. Since the 19th century, avian species (chickens in particular) have been widely used for germ cell research. Previous studies have used chicken PGCs for a variety of research applications, including as a model for studies focusing on germline development. Other applications of chicken PGCs, including conservation efforts for avian species and methods of producing transgenic birds, have further reinforced the importance of these cells. However, much remains to be revealed about the origin and role of PGCs during their development in the chicken. Here, we provide a comprehensive review of chicken PGCs, focusing in particular upon their initial profiles and physiological changes during development as regulated by environmental factors and/or intrinsic mechanisms. We also emphasise sex-dependent differences in PGC development after settlement within the gonads, as well as future applications for avian PGCs. 
PY  - 2018
DO  - 10.1387/ijdb.170283jh
VL  - 62
IS  - 1-2-3
SP  - 145
EP  - 152
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/170283jh
Y2  - 2024/05/03/12:42:33
ER  -