TY  - JOUR
TI  - Galectin-1 enhances the generation of neural crest cells
AU  - Motohashi, Tsutomu
AU  - Nishioka, Masahiro
AU  - Kitagawa, Daisuke
AU  - Kawamura, Norito
AU  - Watanabe, Natsuki
AU  - Wakaoka, Takanori
AU  - Kadoya, Toshihiko
AU  - Kunisada, Takahiro
T2  - The International Journal of Developmental Biology
AB  - Neural crest (NC) cells are multipotent cells that emerge from the dorsal region of the neural tube. After delaminating from the neural tube, NC cells migrate throughout the developing embryo and differentiate into various cells: neurons and glial cells of the peripheral nervous system, melanocytes of skin, and skeletal elements of the face and head. We previously analyzed the gene expression profile of a NC subpopulation isolated from Sox10-IRES-Venus mice and found that the carbohydrate-binding protein, Galectin-1 (Gal-1) was strongly expressed in generating NC cells. In the present study, we identified GAL-1 as a factor that promotes NC cell generation. Gal-1 was significantly expressed in NC cells generated in explanted neural tubes. The presence of GAL-1 enhanced the generation of NC-like cells from mouse embryonic stem (ES) cells. In the differentiation of ES cells into NC-like cells, GAL-1 enhanced neurogenesis in the early stages and facilitated NC-like cell generation in the later stages. GAL-1 also enhanced the generation of NC cells from explanted neural tubes. These results suggest that GAL-1 plays a facilitative role in NC cell generation.
PY  - 2017
DO  - 10.1387/ijdb.160380tm
VL  - 61
IS  - 6-7
SP  - 407
EP  - 413
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/160380tm
Y2  - 2024/11/21/22:42:23
ER  -