TY - JOUR TI - States of G0 and the proliferation-quiescence decision in cells, tissues and during development AU - Sun, Dan AU - Buttitta, Laura T2 - The International Journal of Developmental Biology AB - While cellular proliferation is fundamental to the development of all multicellular organisms, the slowing or stopping of proliferation at the right places and times is equally important for proper tissue and organ development. The non-cycling state of cellular quiescence or “G0” is relatively understudied compared to proliferation, given its prevalence in nature. It may seem that actively proliferating cells undergo a series of dynamic events, while quiescent cells are in a passive, static state. However, studies over the last 10-15 years suggest that quiescence may be more dynamic than previously thought and must also be actively regulated and maintained. This review focuses on recent advances in understanding quiescence or G0 and in particular, on observations about the proliferation-quiescence decision in cell lines, in tissues and during development. We also discuss novel, advanced molecular tools that are likely to enable the field to address outstanding, unresolved questions about cellular quiescence and its regulation. PY - 2017 DO - 10.1387/ijdb.160343LB VL - 61 IS - 6-7 SP - 357 EP - 366 J2 - Int. J. Dev. Biol. LA - en SN - 0214-6282 SN - 1696-3547 UR - https://ijdb.ehu.eus/article/160343LB Y2 - 2024/11/24/19:14:40 ER -