TY  - JOUR
TI  - Annotating the genome by DNA methylation
AU  - Cedar, Howard
AU  - Razin, Aharon
T2  - The International Journal of Developmental Biology
AB  - DNA methylation plays a prominent role in setting up and stabilizing the molecular design of gene regulation and by understanding this process one gains profound insight into the underlying biology of mammals. In this article, we trace the discoveries that provided the foundations of this field, starting with the mapping of methyl groups in the genome and the experiments that helped clarify how methylation patterns are maintained through cell division. We then address the basic relationship between methyl groups and gene repression, as well as the molecular rules involved in controlling this process during development in vivo. Finally, we describe ongoing work aimed at defining the role of this modification in disease and deciphering how it may serve as a mechanism for sensing the environment.
PY  - 2017
DO  - 10.1387/ijdb.160270hc
VL  - 61
IS  - 3-4-5
SP  - 137
EP  - 148
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/160270hc
Y2  - 2024/11/21/14:25:30
ER  -