TY  - JOUR
TI  - Etiology of intracerebral hemorrhage (ICH): novel insights from Zebrafish embryos
AU  - Eisa-Beygi, Shahram
AU  - Rezaei, Mohammad
T2  - The International Journal of Developmental Biology
AB  - Intracerebral hemorrhage (ICH) is the most severe subtype of stroke. Treatment options are scarce and given the high morbidity and mortality, relatively ineffective. Since patients with ICH may have an unknown heritable component, the need to identify potential risk factors necessitates the use of animal models to elucidate the genetic underpinnings of neurovascular development and, thereby, identify candidate regulatory pathways that are likely to be disrupted in patients with ICH. Zebrafish (Danio rerio) exhibits the anatomical and physiological complexity of a closed circulatory system observed in all vertebrates (with arteries, veins and capillaries). Moreover, studies over the last decade, aided by the application of chemical mutagenesis screens, morpholino mediated knockdown approaches and tissue-specific transgenic markers, have paved the way for the identification of several genes and signaling pathways that regulate developmental neurovascular stabilization. We hypothesize that mutations in these genes or pharmacological perturbations of these gene-products may account, at least in part, for the etiology of some forms of spontaneous ICH in humans.
PY  - 2016
DO  - 10.1387/ijdb.160136se
VL  - 60
IS  - 4-5-6
SP  - 119
EP  - 126
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/160136se
Y2  - 2024/11/05/17:18:27
ER  -