TY  - JOUR
TI  - The different steps of skin formation in vertebrates.
AU  - Olivera-Martinez, Isabel
AU  - Viallet, Jean P
AU  - Michon, Frederic
AU  - Pearton, David J
AU  - Dhouailly, Danielle
T2  - The International Journal of Developmental Biology
AB  - Skin morphogenesis occurs following a continuous series of cell-cell interactions which can be subdivided into three main stages: 1- the formation of a dense dermis and its overlying epidermis in the future appendage fields (macropattern); 2- the organization of these primary homogeneous fields into heterogeneous ones by the appearance of cutaneous appendage primordia (micropattern) and 3- cutaneous appendage organogenesis itself. In this review, we will first show, by synthesizing novel and previously published data from our laboratory, how heterogenetic and heterospecific dermal/epidermal recombinations have allowed us to distinguish between the respective roles of the dermis and the epidermis. We will then summarize what is known from the work of many different research groups about the molecular signaling which mediates these interactions in order to introduce the following articles of this Special Issue and to highlight what remains to done.
PY  - 2004
DO  - 10.1387/ijdb.15272376
VL  - 48
IS  - 2-3
SP  - 107
EP  - 115
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/15272376
Y2  - 2024/11/21/18:04:43
ER  -