TY  - JOUR
TI  - Immunogenic cell death
AU  - Garg, AbhishekD.
AU  - Dudek-Peric, AleksandraM.
AU  - Romano, Erminia
AU  - Agostinis, Patrizia
T2  - The International Journal of Developmental Biology
AB  - Currently, it is widely acknowledged that a proactive anticancer immunosurveillance mechanism takes part in the rejection of neoplastic lesions before they progress towards a benign or malignant tumour. However in cases of very aggressive neoplastic lesions consisting of cells with high mutational diversity, cancer cell variants might be formed that are capable of evading host defence systems against uncontrolled proliferation and anticancer immunosurveillance. This is mainly accomplished through the exhibition of low immunogenicity, which is a particularly important stumbling block in the revival of long-lasting as well as stable anticancer immunity. Recently, it has emerged emphatically that inciting a cancer cell death routine, associated with the activation of danger signalling pathways evoking emission of damage-associated molecular patterns (DAMPs), markedly increases the immunogenicity of dying cancer cells. This cell death pathway has been termed “immunogenic cell death” (ICD). In the present review we introduce this concept and discuss its characteristics in detail. We also discuss in detail the various molecular, immunological and operational determinants of ICD.
PY  - 2015
DO  - 10.1387/ijdb.150061pa
VL  - 59
IS  - 1-2-3
SP  - 131
EP  - 140
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/150061pa
Y2  - 2024/11/21/18:16:41
ER  -