TY - JOUR TI - 'De-evolution' of Drosophila toward a more generic mode of axis patterning. AU - Lynch, Jeremy AU - Desplan, Claude T2 - The International Journal of Developmental Biology AB - The genetics of the establishment of the primary axes of the early embryo have been worked out in great detail Drosophila. However, evidence has accumulated that Drosophila employs a mode of patterning that is not shared with most insects. In particular, the use of the morphogenic gradient of the Bicoid homeoprotein appears to be a novel addition to the fly developmental toolkit. To better understand the ancestral mode of patterning that is probably more widely used by insects, several groups have used Evo-Devo approaches as well as sophisticated genetic manipulations of Drosophila to achieve some form of 'de-evolution' of this derived insect. Genetic manipulations of the beetle Tribolium and the wasp Nasonia have validated most of these results. PY - 2003 VL - 47 IS - 7-8 SP - 497 EP - 503 J2 - Int. J. Dev. Biol. LA - en SN - 0214-6282 SN - 1696-3547 UR - https://ijdb.ehu.eus/article/14756325 Y2 - 2024/12/14/04:26:27 ER -