TY  - JOUR
TI  - Epigenetics and imprinting in human disease
AU  - Kalish, JenniferM.
AU  - Jiang, Connie
AU  - Bartolomei, MarisaS.
T2  - The International Journal of Developmental Biology
AB  - Most genes are expressed from both parental chromosomes; however, a small number of genes in mammals are imprinted and expressed in a parent-of-origin specific manner. These imprinted genes play an important role in embryonic and extraembryonic growth and development, as well as in a variety of processes after birth. Many imprinted genes are clustered in the genome with the establishment and maintenance of imprinted gene expression governed by complex epigenetic mechanisms. Dysregulation of these epigenetic mechanisms as well as genomic mutations at imprinted gene clusters can lead to human disease.
PY  - 2014
DO  - 10.1387/ijdb.140077mb
VL  - 58
IS  - 2-3-4
SP  - 291
EP  - 298
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/140077mb
Y2  - 2024/11/23/11:53:58
ER  -