TY  - JOUR
TI  - The role of trophoblastic microRNAs in placental viral infection
AU  - Mouillet, Jean-Francois
AU  - Ouyang, Yingshi
AU  - Bayer, Avraham
AU  - Coyne, CarolynB.
AU  - Sadovsky, Yoel
T2  - The International Journal of Developmental Biology
AB  - During the past decade, various types of small non-coding RNAs were found to be expressed in all kingdoms and phyla of life. Intense research efforts have begun to shed light on their biological functions, although much remains to be determined in order to fully characterize their scope of biological action. Typically, small RNAs provide sequence specificity to a protein complex that is driven to silence a long target RNA. MicroRNAs (miRNAs) are small RNAs that are coded in the genome of most eukaryotes, and contribute to the cellular identity by regulating cell-specific gene networks by translational repression or degradation of mRNA. These effects commonly fine-tune gene expression associated with developmental or environmental cues. Different cell types can be characterized by their distinctive cellular miRNA landscape. The human placenta expresses a unique set of miRNAs, a high proportion of which is derived from a large cluster located on chromosome 19, (termed chromosome 19 miRNA cluster, or C19MC). Interestingly, a fraction of these placenta-enriched miRNAs are released to the extracellular environment through exosomes that were recently found to induce an antiviral immunity. In this review, we explore relevant placental viral infections and discuss the antiviral role of exosome-packaged placental C19MC miRNAs in this context.
PY  - 2014
DO  - 10.1387/ijdb.130349ys
VL  - 58
IS  - 2-3-4
SP  - 281
EP  - 289
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/130349ys
Y2  - 2024/11/05/13:19:09
ER  -