TY  - JOUR
TI  - The roles of bacterial and host plant factors in <I>Agrobacterium</I>-mediated genetic transformation
AU  - Lacroix, Benoît
AU  - Citovsky, Vitaly
T2  - The International Journal of Developmental Biology
AB  - The genetic transformation of plants mediated by Agrobacterium tumefaciens represents an essential tool for both fundamental and applied research in plant biology. For a successful infection, culminating in the integration of its transferred DNA (T-DNA) into the host genome, Agrobacterium relies on multiple interactions with host-plant factors. Extensive studies have unraveled many of such interactions at all major steps of the infection process: activation of the bacterial virulence genes, cell-cell contact and macromolecular translocation from Agrobacterium to host cell cytoplasm, intracellular transit of T-DNA and associated proteins (T-complex) to the host cell nucleus, disassembly of the T-complex, T-DNA integration, and expression of the transferred genes. During all these processes, Agrobacterium has evolved to control and even utilize several pathways of host-plant defense response. Studies of these Agrobacterium-host interactions substantially enhance our understanding of many fundamental cellular biological processes and allow improvements in the use of Agrobacterium as a gene transfer tool for biotechnology.
PY  - 2013
DO  - 10.1387/ijdb.130199bl
VL  - 57
IS  - 6-7-8
SP  - 467
EP  - 481
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/130199bl
Y2  - 2024/12/22/08:20:36
ER  -