TY  - JOUR
TI  - Epigenetic features of testicular germ cell tumours in relation to epigenetic characteristics of foetal germ cells 
AU  - Kristensen, DinaG.
AU  - Skakkebæk, NielsE.
AU  - Rajpert-De Meyts, Ewa
AU  - Almstrup, Kristian
T2  - The International Journal of Developmental Biology
AB  - Foetal development of germ cells is a unique biological process orchestrated by cellular specification, migration and niche development in concert with extensive epigenetic and transcriptional programs. Many of these processes take place early in foetal life and are hence very difficult to study in humans. However, the common precursor of testicular cancers – the carcinoma in situ (CIS) cell – is thought to be an arrested foetal germ cell. Therefore studies of CIS cells may leverage information on human foetal germ cell development and, in particular, when neoplastic transformation is initiated. In this review, we will focus on current knowledge of the epigenetics of CIS cells and relate it to the epigenetic changes occurring in early developing germ cells of mice during specification, migration and colonization. We will focus on DNA methylation and some of the best studied histone modifications like H3K9me2, H3K27me3 and H3K9ac. We also show that CIS cells contain high levels of H3K27ac, which is known to mark active enhancers. Proper epigenetic reprogramming seems to be a pre-requisite of normal foetal germ cell development and we propose that alterations in these programs may be a pathogenic event in the initiation of testicular germ cell cancer. Even though only sparse information is available on epigenetic cues in human foetal germ cells, these indicate that the developmental patterns differ from the findings in mice and emphasize the need for further studies of foetal germ cell development in humans.
PY  - 2013
DO  - 10.1387/ijdb.130142ka
VL  - 57
IS  - 2-3-4
SP  - 309
EP  - 317
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/130142ka
Y2  - 2024/11/24/01:13:56
ER  -