TY  - JOUR
TI  - Patient with two secondary somatic-type malignancies in a late recurrence of a testicular non-seminoma: illustration of potential and flaw of the cancer stem cell therapy concept
AU  - Oosterhuis, J. Wolter
AU  - Peeters, SuzanneH. P.
AU  - Smit, VincentT. H. B. M
AU  - Stoop, Hans
AU  - Looijenga, LeendertH. J.
AU  - Elzevier, HenkW.
AU  - Osanto, Suzanne
T2  - The International Journal of Developmental Biology
AB  - Here, we report the case of a patient with a non-seminoma of the left testicle, with an intestinal-type adenocarcinoma and a low grade leiomyosarcoma in a late recurrence 19 years after initial diagnosis. The history of the patient, alive with disease 21 years after initial treatment, illustrates the potential and flaw of the cancer stem cell therapy concept. In addition, it is proposed that residual mature teratoma can be regarded as normalization of cancer due to embryonic patterning, and the development of a secondary somatic-type malignancy as failure of normalization.
PY  - 2013
DO  - 10.1387/ijdb.130141jo
VL  - 57
IS  - 2-3-4
SP  - 153
EP  - 157
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/130141jo
Y2  - 2024/11/21/18:59:29
ER  -