TY  - JOUR
TI  - The circadian gene Clock is required for the correct early expression of the head specific gene Otx2.
AU  - Morgan, Richard
T2  - The International Journal of Developmental Biology
AB  - The circadian cycle is a universal molecular mechanism for imposing cyclical control on cellular processes. Here we have examined the role of one of the crucial circadian genes, Clock, in early Xenopus development. We show that a dominant negative version of Clock can block the function of the endogenous Clock gene. Doing so during early development reduces Otx2 expression in a highly specific manner and results in anterior defects. Together with previous work (Green et al. (2001) Mech. Dev. 105-110), these results suggest that a positive regulatory loop exists between Clock and Otx2.
PY  - 2002
VL  - 46
IS  - 8
SP  - 999
EP  - 1004
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/12533023
Y2  - 2024/11/24/14:09:22
ER  -