TY  - JOUR
TI  - The role of the Eph-ephrin signalling system in the regulation of developmental patterning.
AU  - Coulthard, Mark G
AU  - Duffy, Shannon
AU  - Down, Michelle
AU  - Evans, Betty
AU  - Power, Maryanne
AU  - Smith, Fiona
AU  - Stylianou, Con
AU  - Kleikamp, Sabine
AU  - Oates, Andrew
AU  - Lackmann, Martin
AU  - Burns, Gordon F
AU  - Boyd, Andrew W
T2  - The International Journal of Developmental Biology
AB  - The Eph and ephrin system, consisting of fourteen Eph receptor tyrosine kinase proteins and nine ephrin membrane proteins in vertebrates, has been implicated in the regulation of many critical events during development. Binding of cell surface Eph and ephrin proteins results in bi-directional signals, which regulate the cytoskeletal, adhesive and motile properties of the interacting cells. Through these signals Eph and ephrin proteins are involved in early embryonic cell movements, which establish the germ layers, cell movements involved in formation of tissue boundaries and the pathfinding of axons. This review focuses on two vertebrate models, the zebrafish and mouse, in which experimental perturbation of Eph and/or ephrin expression in vivo have provided important insights into the role and functioning of the Eph/ephrin system.
PY  - 2002
VL  - 46
IS  - 4
SP  - 375
EP  - 384
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/12141423
Y2  - 2024/11/05/15:23:12
ER  -