TY  - JOUR
TI  - The role of Akt signalling in the mammalian ovary
AU  - Cecconi, Sandra
AU  - Mauro, Annunziata
AU  - Cellini, Valerio
AU  - Patacchiola, Felice
T2  - The International Journal of Developmental Biology
AB  - The serine/threonine protein kinase Akt is involved in many cellular processes including cell growth, survival, proliferation and metabolism. Akt activity is modulated downstream of phosphatidylinositol-3-kinase (PI3K) in response to different extracellular stimuli. In the mammalian ovary,  Akt collaborates with other kinases in the regulation of coordinate follicle and oocyte development. Akt determines the pool of primordial follicles and the transition from quiescent to growing phase. In addition, the kinase modulates granulosa cell apoptosis throughout folliculogenesis. In oocytes Akt participates in the control of meiosis resumption and, at metaphase II stage, regulates polar body emission and spindle organization. Its inhibition negatively affects preimplantation embryo development. As a consequence of such a central role, Akt dysregulation is associated with several human diseases including infertility and ovarian cancer.
PY  - 2012
DO  - 10.1387/ijdb.120146sc
VL  - 56
IS  - 10-11-12
SP  - 809
EP  - 817
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/120146sc
Y2  - 2024/11/05/13:16:05
ER  -