TY - JOUR TI - Planarians in pharmacology: parthenolide is a specific behavioral antagonist of cocaine in the planarian Girardia tigrina AU - Pagán, OnéR. AU - Baker, Debra AU - Deats, Sean AU - Montgomery, Erica AU - Tenaglia, Matthew AU - Randolph, Clinita AU - Kotturu, Dharini AU - Tallarida, Christopher AU - Bach, Daniel AU - Wilk, Galia AU - Rawls, Scott AU - Raffa, RobertB. T2 - The International Journal of Developmental Biology AB - Planarians are traditional animal models in developmental and regeneration biology. Recently, these organisms are arising as vertebrate-relevant animal models in neuropharmacology. Using an adaptation of published behavioral protocols, we have described the alleviation of cocaine-induced planarian seizure-like movements (pSLM) by a naturally-occurring sesquiterpene lactone, parthenolide. Interestingly, parthenolide does not prevent the expression of pSLM induced by amphetamines; in vertebrates, amphetamines interact with the same protein target as cocaine. Parthenolide is also unable to prevent pSLM elicited by the cholinergic com-pounds nicotine and cytisine or by the glutamatergic agents L- or D- glutamic acid or NMDA. Thus, we conclude that parthenolide is a specific anti-cocaine agent in this experimental organism. PY - 2012 DO - 10.1387/ijdb.113486op VL - 56 IS - 1-2-3 SP - 193 EP - 196 J2 - Int. J. Dev. Biol. LA - en SN - 0214-6282 SN - 1696-3547 UR - https://ijdb.ehu.eus/article/113486op Y2 - 2024/10/11/03:27:31 ER -