TY  - JOUR
TI  - Planarians in pharmacology: parthenolide is a specific behavioral antagonist of cocaine in the planarian <I>Girardia tigrina</I>
AU  - Pagán, OnéR.
AU  - Baker, Debra
AU  - Deats, Sean
AU  - Montgomery, Erica
AU  - Tenaglia, Matthew
AU  - Randolph, Clinita
AU  - Kotturu, Dharini
AU  - Tallarida, Christopher
AU  - Bach, Daniel
AU  - Wilk, Galia
AU  - Rawls, Scott
AU  - Raffa, RobertB.
T2  - The International Journal of Developmental Biology
AB  - Planarians are traditional animal models in developmental and regeneration biology. Recently, these organisms are arising as vertebrate-relevant animal models in neuropharmacology. Using an adaptation of published behavioral protocols, we have described the alleviation of cocaine-induced planarian seizure-like movements (pSLM) by a naturally-occurring sesquiterpene lactone, parthenolide. Interestingly, parthenolide does not prevent the expression of pSLM induced by amphetamines; in vertebrates, amphetamines interact with the same protein target as cocaine. Parthenolide is also unable to prevent pSLM elicited by the cholinergic com-pounds nicotine and cytisine or by the glutamatergic agents L- or D- glutamic acid or NMDA. Thus, we conclude that parthenolide is a specific anti-cocaine agent in this experimental organism.
PY  - 2012
DO  - 10.1387/ijdb.113486op
VL  - 56
IS  - 1-2-3
SP  - 193
EP  - 196
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/113486op
Y2  - 2024/11/05/13:17:40
ER  -