TY  - JOUR
TI  - xCOUP-TF-B regulates <I>xCyp26</I> transcription and modulates retinoic acid signaling for anterior neural patterning in <I>Xenopus</I>
AU  - Tanibe, Misaki
AU  - Ishiura, Sho-Ichi
AU  - Asashima, Makoto
AU  - Michiue, Tatsuo
T2  - The International Journal of Developmental Biology
AB  - Early embryogenesis in Xenopus development depends on correct anterior-posterior (A-P) neural patterning during gastrulation. It is known that high levels of retinoic acid (RA), a major intracellular signaling molecule, determine posterior cell fate, also reflecting an involvement in A-P neural patterning. Here we show that the known RA effector, xCOUP-TF, plays important roles in head development of Xenopus embryo. xCOUP-TF-B injection into the dorsal region of embryos induced formation of an abnormal head with small eyes. Analysis of brain marker gene expression revealed that xCOUP-TF-B injection induced slight anteriorization in embryos and attenuated the effects of RA treatment. This anteriorization effect was enhanced when xCOUP-TF-B was co-injected with xCyp26A or xCyp26C, which are known RA metabolizing factors. Furthermore, xCOUP-TF-B injection enhanced xCyp26A/C transcription. Together, these results suggest that xCOUP-TF and xCyp26 are both regulated by Wnt signaling, and cooperatively function in RA signaling to affect A-P neural patterning.
PY  - 2012
DO  - 10.1387/ijdb.113482mt
VL  - 56
IS  - 4
SP  - 239
EP  - 244
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/113482mt
Y2  - 2024/11/23/12:57:25
ER  -