TY  - JOUR
TI  - Stemness in <I>Hydra</I> - a current perspective
AU  - Hobmayer, Bert
AU  - Jenewein, Marcell
AU  - Eder, Dominik
AU  - Eder, Marie-Kristin
AU  - Glasauer, Stella
AU  - Gufler, Sabine
AU  - Hartl, Markus
AU  - Salvenmoser, Willi
T2  - The International Journal of Developmental Biology
AB  - Hydra is a classic and simple model for pattern formation and regeneration research. More recently, it has also been promoted as a model to study ancestral stem cell biology. Three independent cell lineages form the body of the polyp and exhibit characteristics of stem cell systems. In order to define differences in stemness between the ectodermal and endodermal epitheliomuscular cell lineages and the interstitial cell lineage, we compare cellular properties and decision making. We argue that these three lineages are expected to show substantial variation in their stemness-related gene regulatory networks. Finally, we discuss Wnt signalling pathways and Myc oncoproteins, which are beginning to offer a perspective on how proliferation and differentiation might be regulated.
PY  - 2012
DO  - 10.1387/ijdb.113426bh
VL  - 56
IS  - 6-7-8
SP  - 509
EP  - 517
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/113426bh
Y2  - 2024/11/21/17:00:17
ER  -