TY  - JOUR
TI  - Exosome signaling in mammary gland development and cancer
AU  - Hendrix, An
AU  - Hume, AlistairN.
T2  - The International Journal of Developmental Biology
AB  - Exosomes are 40-100 nm intraluminal vesicles that are released by cells upon fusion of multivesicular endosomes (MVEs) with the plasma membrane. The Rab family of small GTPases, including Rab27A and Rab27B, control different steps of exosome release, including transport of MVEs and docking at the plasma membrane. Exosomes are long range message particles that mediate communication between cells in physiological conditions such as mammary gland development and lactation, but also in pathology such as breast cancer. Metastasis is the culmination of cancer progression and involves a complex interaction with the local and distant environment. Exosome messaging contributes to tumor environment interactions such as immune escape, thrombosis and myofibroblast differentiation, thereby modulating metastatic niche preparation.
PY  - 2011
DO  - 10.1387/ijdb.113391ah
VL  - 55
IS  - 7-8-9
SP  - 879
EP  - 887
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/113391ah
Y2  - 2024/11/21/14:01:55
ER  -