TY  - JOUR
TI  - The mammary myoepithelial cell
AU  - Moumen, Mejdi
AU  - Chiche, Aurélie
AU  - Cagnet, Stéphanie
AU  - Petit, Valérie
AU  - Raymond, Karine
AU  - Faraldo, MarisaM.
AU  - Deugnier, Marie-Ange
AU  - Glukhova, MarinaA.
T2  - The International Journal of Developmental Biology
AB  - Over the last few years, the discovery of basal-type mammary carcinomas and the association of the regenerative potential of the mammary epithelium with the basal myoepithelial cell population have attracted considerable attention to this second major mammary lineage. However, many questions concerning the role of basal myoepithelial cells in mammary morphogenesis, functional differentiation and disease remain unanswered. Here, we discuss the mechanisms that control the myoepithelial cell differentiation essential for their contractile function, summarize new data concerning the roles played by cell-extracellular matrix (ECM), intercellular and paracrine interactions in the regulation of various aspects of the mammary basal myoepithelial cell functional activity. Finally, we analyze the contribution of the basal myoepithelial cells to the regenerative potential of the mammary epithelium and tumorigenesis.
PY  - 2011
DO  - 10.1387/ijdb.113385mm
VL  - 55
IS  - 7-8-9
SP  - 763
EP  - 771
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/113385mm
Y2  - 2024/11/25/06:55:25
ER  -