TY  - JOUR
TI  - <I>Hox</I> collinearity - a new perspective
AU  - Durston, AntonyJ.
AU  - Jansen, HansJ.
AU  - In der Rieden, Paul
AU  - Hooiveld, MichielH. W.
T2  - The International Journal of Developmental Biology
AB  - Hox collinearity is a spectacular phenomenon that has excited life scientists since its discovery in 1978. Two mechanisms have been proposed to explain the spatially sequential pattern of Hox gene expression in animal embryonic development: interactions among Hox genes, or the progressive opening of chromatin in the Hox clusters, from 3' to 5'. A review of the evidence across different species and developmental stages points to the universal involvement of trans-acting factors and cell-cell interactions. The evidence focuses attention on interactions between Hox genes and on the vertebrate somitogenesis clock. These novel conclusions open new perspectives for the field.
PY  - 2011
DO  - 10.1387/ijdb.113358ad
VL  - 55
IS  - 10-11-12
SP  - 899
EP  - 908
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/113358ad
Y2  - 2024/12/22/13:32:42
ER  -