TY  - JOUR
TI  - The BMP antagonists cerberus-like and noggin do not interact during mouse forebrain development.
AU  - Borges, A C
AU  - Marques, S
AU  - Belo, J A
T2  - The International Journal of Developmental Biology
AB  - Mouse cerberus-like encodes for a secreted factor of the Cerberus/Dan family. This molecule has neural inducing capabilities and can bind to BMP-4 and nodal molecules in the extracellular space. When cerberus-like is inactivated, its function may be compensated for another molecule, since no abnormalities can be observed in the mouse mutant. Compensation mechanisms have been shown to occur between the BMP antagonists chordin and noggin. Here we report the generation of cerberus-like-/-; noggin-/- double mutants to uncover a possible compensation by noggin in cer-l-/- mutant. Double mutants were obtained and failed to show any further detectable defects beside the ones presented by the noggin-/- single mutant. Contrarily to chordin and noggin, mouse cerberus-like and noggin cannot compensate for each other during mouse embryogenesis.
PY  - 2001
VL  - 45
IS  - 2
SP  - 441
EP  - 444
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/11330864
Y2  - 2024/11/05/15:25:12
ER  -