TY  - JOUR
TI  - Amphibian embryos as a model system for organ engineering: in vitro induction and rescue of the heart anlage.
AU  - Grunz, H
T2  - The International Journal of Developmental Biology
AB  - Beating hearts can be induced under in vitro conditions when the dorsal blastopore lip (including the zone of Spemann organizer) is treated with Suramin. In contrast, untreated organizer forms dorsal mesodermal derivatives as notochord and somites. When those in vitro produced heart precursor tissues are transplanted ectopically in the posterior trunk area of early larvae, secondary beating heart structures will be formed. Furthermore, the replacement of the heart primordium of the host embryo by heart tissue induced under in vitro conditions will result in the rescue of the heart anlage. This model could be a valuable tool for the study of the multi-step molecular mechanisms of heart structure induction under in vitro conditions and vasculogenesis after transplantation into the host embryo.
PY  - 1999
VL  - 43
IS  - 4
SP  - 361
EP  - 364
J2  - Int. J. Dev. Biol.
LA  - en
SN  - 0214-6282
SN  - 1696-3547
UR  - https://ijdb.ehu.eus/article/10470654
Y2  - 2024/11/23/16:41:57
ER  -